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Breakthrough

Zhigang He makes PTEN breakthrough in optic nerve. Dr. He’s seminal article published in Science magazine

2008
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Axonis Inc Founded

Company Founded to protect IP related to PTEN and regeneration.

2009
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Collaboration

2009:  Os Steward begins collaboration with Zhigang He.

2009
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Patents

Execution of option on Patents from Children’s Hospital Boston.

2010
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axon regeneration after SCI

PTEN inhibition leads to unprecedented axon regeneration after SCI. Article published in Nature Neuroscience.

2010
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SOCS3

Zhigang He combines PTEN inhibition with SOCS3 for synergistic effect.

2010
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shRNA construct

Os Steward develops shRNA construct capable of knocking down PTEN expression.

2013
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AAV

Os Steward AAV (adeno associated virus) vector with shRNA for in vivo treatments.

2013
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Journal of Neuroscience paper

Dr. Steward publishes paper in Journal of Neuroscience showing dramatic recovery in adult rats with acute spinal cord injury.

2014
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Regeneration of axons

Kai Liu shows regeneration of axons in chronic spinal cord injury.

2015
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Mice study

No tumor growth observed in two year old pTEN deleted mice.

2016
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Friends and Family

Launch of friends and family offering.

2017 - present
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INTERACT Meeting Prep

Launch of presentations to potential VC/angel funders.

2018 - present
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Exclusive patent license

Execution of exclusive license of Children’s Hospital patents for PTEN interventions for nervous system disorders.

2019