What’s Been Invested
Since 2008, approximately $5 million has been contributed to PTEN related research in the laboratories of Drs. He and Steward through the National Institute of Health, private foundation grants and philanthropic donations which has verified the proof of concept for this therapy.
We Are Seeking
We are now seeking to raise additional investment to evolve the PTEN inhibition and viral vector delivery system for therapy. Contact us if you’re interested in learning more.
Timeline and Milestones
Breakthrough
Zhigang He makes PTEN breakthrough in optic nerve. Dr. He’s seminal article published in Science magazine
2008
Axonis Inc Founded
Company Founded to protect IP related to PTEN and regeneration.
2009
Collaboration
2009: Os Steward begins collaboration with Zhigang He.
2009
Patents
Execution of option on Patents from Children’s Hospital Boston.
2010
axon regeneration after SCI
PTEN inhibition leads to unprecedented axon regeneration after SCI. Article published in Nature Neuroscience.
2010
SOCS3
Zhigang He combines PTEN inhibition with SOCS3 for synergistic effect.
2010
shRNA construct
Os Steward develops shRNA construct capable of knocking down PTEN expression.
2013
AAV
Os Steward AAV (adeno associated virus) vector with shRNA for in vivo treatments.
2013
Journal of Neuroscience paper
Dr. Steward publishes paper in Journal of Neuroscience showing dramatic recovery in adult rats with acute spinal cord injury.
2014
Regeneration of axons
Kai Liu shows regeneration of axons in chronic spinal cord injury.
2015
Mice study
No tumor growth observed in two year old pTEN deleted mice.
2016
Friends and Family
Launch of friends and family offering.
2017 - present
INTERACT Meeting Prep
Launch of presentations to potential VC/angel funders.
2018 - present
Exclusive patent license
Execution of exclusive license of Children’s Hospital patents for PTEN interventions for nervous system disorders.
2019